Plasma Protein Guide

Serum protein testing has been an integral, although underutilized, part of clinical laboratory science for many years. As appreciation grows for the power of these measurements in clinical practice so does a need for continuing education.

Through an educational grant from Dade Behring, Inc., FBR has developed this 152-page guide on serum protein utility and interpretation for day to day use by practitioners and laboratorians. This 4½" x 7" guide contains a distillation of the world's literature on the subject, is fully indexed, and is presented by a given disease state (Section I), as well as by individual proteins (Section II).

Outline of Contents

SECTION I.A.: Non-Disease-Specific Effects on Serum Proteins

INFLAMMATION

OVERVIEW

GENERAL APPLICATIONS OF PROTEIN ANALYSIS IN INFLAMMATION

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SPECIFIC APPLICATIONS OF PROTEIN ANALYSIS IN INFLAMMATION

SERUM PROTEIN INTERPRETATIONS CONFOUNDED BY INFLAMMATION

DRUG AND HORMONE EFFECTS ON SERUM PROTEINS

NUTRITIONAL ASSESSMENT

OVERVIEW

FACTORS CONFOUNDING PROTEIN DATA IN NUTRITIONAL ASSESSMENT

ASSESSMENT AND MONITORING OF NUTRITIONAL STATUS

NUTRITIONAL MARKERS IN PROGNOSIS

SECTION I.B.: Clinical Disease and Serum Protein Use

ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

OVERVIEW

CARDIOVASCULAR DISEASE

ACUTE MYOCARDIAL INFARCTION

ISCHEMIC STROKE

ENDOCRINE DISEASE

DIABETES MELLITUS

THYROID DISEASE

GASTROINTESTINAL DISEASE

PROTEIN-LOSING GASTROENTEROPATHY

GASTROINTESTINAL MALIGNANCY

CHRONIC INFLAMMATORY BOWEL DISEASE

HEMATOLOGIC DISEASE

MONOCLONAL GAMMOPATHY

ANEMIA

LIVER DISEASE

INHERITED LIVER DISEASES

VIRAL HEPATITIS

CHRONIC LIVER DISEASE

NEUROLOGIC DISEASE

MULTIPLE SCLEROSIS

PARAPROTEINEMIC NEUROPATHY

PULMONARY DISEASE

CHRONIC OBSTRUCTIVE PULMONARY DISEASE

ASTHMA

LUNG CANCER

RENAL DISEASE

NEPHROTIC SYNDROME

CHRONIC RENAL FAILURE

GLOMERULONEPHRITIS

HEMOSTATIC BALANCE IN RENAL DISEASE

RHEUMATIC DISEASE

ANKYLOSING SPONDYLITIS

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JUVENILE RHEUMATOID ARTHRITIS

MIXED CONNECTIVE TISSUE DISEASE

OSTEOARTHRITIS

POLYMYALGIA RHEUMATICA/GIANT CELL ARTERITIS

POLYMYOSITIS/DERMATOMYOSITIS

RHEUMATOID ARTHRITIS

SJÖGREN'S SYNDROME

SYSTEMIC LUPUS ERYTHEMATOSUS

SYSTEMIC SCLEROSIS/SCLERODERMA

SECTION II: General Information on Serum Proteins

ALBUMIN

ALPHA-1-ACID GLYCOPROTEIN

ALPHA-1- ANTICHYROMOTRYPSIN

ALPHA-1-ANTITRYPSIN

ALPHA-1-MICROGLOBULIN

ALPHA-2-MACROGLOBULIN

ANTITHROMBIN III

APOLIPOPROTEIN A-1

APOLIPOROTEIN B

BETA-2-MICROGLOBULIN

CERULOPLASMIN

COMPLEMENT COMPONENT 3

COMPLEMENT COMPONENT 4

C1 ESTERASE INHIBITOR

C-REACTIVE PROTEIN

CYSTATIN C

FERRITIN

FIBRINOGEN

FIBRONECTIN

HAPTOGLOBIN

HEMOPEXIN

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IMMUNOGLOBULIN A

IMMUNOGLOBULIN D

IMMUNOGLOBULIN E

IMMUNOGLOBULIN G

IMMUNOGLOBULIN M

IMMUNOGLOBULIN LIGHT CHAINS (kappa/lambda)

LIPOPROTEIN(a)

MANNOSE-BINDING PROTEIN

MYOGLOBIN

PLASMINOGEN

PREALBUMIN

RETINOL-BINDING PROTEIN

RHEUMATOID FACTOR

SERUM AMYLOID A

SOLUBLE TRANSFERRIN RECEPTOR

TRANSFERRIN

REFERENCES FOR REFERENCE RANGES

Book Reviews:

EK: This book is useful for interpretation of test results, as well as providing guidance regarding which test is (or is not) appropriate to order and why (or why not). I learned a lot reviewing it. Section II is helpful regarding background information about each protein. I imagine referring to this section once the decision to order a specific test is made. The size and length of the document are conducive to frequent and easy use. This book is definitely appropriate for house staff, internists, general practictioners. I would think it appropriate also for pediatricians and specialists as well, for all of the above-mentioned reasons.

RS: It's particularly useful to have sections on particular disease entities and sections on each protein. The guide can be used on many different levels by medical students, residents, internists, specialists, etc. The guide is most helpful in deciding which tests to order for a suspected diagnosis; interpreting protein results already in a patient's chart and as a source of background material for serum protein testing. It's wonderful!

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