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Anti-Phospholipid Antibodies (APA) Cardiolipin (aCL) - Phosphatidylserine (aPL) IgA, IgG, IgM antibodies by ELISA Prenatal Screening Laboratory
Relevance The presence of anti-phospholipid antibodies is associated with systemic lupus erythematosus (SLE) or lupus-like disease, arterial or venous thrombosis, thrombocytopenia, recurrent pregnancy loss, postnatal maternal complications, migraine headaches, cerebrovascular accident, transient ischemic attack, or stroke. Notes Includes three specific assays for anticardiolipin (aCL) and three antiphosphatidylserine (aPL) antibodies. Some laboratories have reported that 10-25% of APA positive patients were positive for aPL but negative for aCL. The FBR performs both the aCL and aPL assays as part of the Anti-phospholipid antibody syndrome panel (APS). Testing for both phospholipid antibodies is more clinically relevant than testing for either alone; however, both aCL and aPL may be ordered as individual tests. Reference(s)
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