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Anti-Phospholipid Antibodies Syndrome Panel (APS)
Cardiolipin (aCL) - Phosphatidylserine (aPL) IgG, IgM, and IgA antibodies against CL and PS by ELISA, Lupus-like Anticoagulant (LAC)
- Coagulation screening assays: dilute Russell Viper Venom Test (dRVVT) and Activated Partial Thromboplastin Time (APTT)
Prenatal Screening Laboratory
Specimen Required:
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aCL and aPL: Serum: 2 mL
Room temperature or 4°C
LAC: Refer to Special Handling Requirements.
| Days Test Set Up:
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Run once per week
| Analytic Time:
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48 hours
| Reference Values:
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aCL and aPL: > 98 percentile = Elevated
Reported out in standardized units as IgG Phospholipid Level (GPL), IgM Phospholipid Level (MPL), IgA Phospholipid Level (APL).
LAC: < mean + 2SD = negative
| CPT Code(s):
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86147 X 3, 86148 X 3, 85613, 85730
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Relevance
The presence of both phospholipid antibodies and LAC is associated with systemic lupus erythematosus (SLE) or lupus-like disease, arterial or venous thrombosis, thrombocytopenia, recurrent pregnancy loss, postnatal maternal complications, migraine headaches, cerebrovascular accident, transientischemic attack, or stroke.
Notes
See APA and LAC tests descriptions for more information.
Reference(s)
- Hughes GRV: The antiphospholipid syndrome: 10 years on. Lancet 1993, 342:341.
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