Anti-Phospholipid Antibodies Syndrome Panel (APS)
Prenatal Screening Laboratory
Cardiolipin (aCL) - Phosphatidylserine (aPL) IgG, IgM, and IgA antibodies against CL and PS by ELISA, Lupus-like Anticoagulant (LAC)
Specimen Required:
aCL and aPL: Serum: 2 mL
Room temperature or 4°C
LAC: Refer to Special Handling Requirements.
Days Test Set Up:
Run once per week
Analytic Time:
48 hours
Reference Values:
aCL and aPL: > 98 percentile = Elevated
Reported out in standardized units as
IgG Phospholipid Level (GPL),
IgM Phospholipid Level (MPL),
IgA Phospholipid Level (APL).
LAC: < mean + 2SD = negative
CPT Code(s):
86147 X 3, 86148 X 3, 85613, 85730
Relevance:
The presence of both phospholipid antibodies and LAC is associated with systemic lupus erythematosus (SLE) or lupus-like disease, arterial or venous thrombosis, thrombocytopenia, recurrent pregnancy loss, postnatal maternal complications, migraine headaches, cerebrovascular accident, transientischemic attack, or stroke.
Notes:
See APA and LAC tests descriptions for more information.
Reference(s)