Anti-Phospholipid Antibodies Syndrome Panel (APS)

Prenatal Screening Laboratory

Cardiolipin (aCL) - Phosphatidylserine (aPL) IgG, IgM, and IgA antibodies against CL and PS by ELISA, Lupus-like Anticoagulant (LAC)

• Coagulation screening assays: dilute Russell Viper Venom Test (dRVVT) and Activated Partial Thromboplastin Time (APTT)

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Specimen Required:

aCL and aPL: Serum: 2 mL

Room temperature or 4°C

LAC: Refer to Special Handling Requirements.

Days Test Set Up:

Run once per week

Analytic Time:

48 hours

Reference Values:

aCL and aPL: > 98 percentile = Elevated

Reported out in standardized units as
IgG Phospholipid Level (GPL),
IgM Phospholipid Level (MPL),
IgA Phospholipid Level (APL).

LAC: < mean + 2SD = negative

CPT Code(s):

86147 X 3, 86148 X 3, 85613, 85730

Relevance:

The presence of both phospholipid antibodies and LAC is associated with systemic lupus erythematosus (SLE) or lupus-like disease, arterial or venous thrombosis, thrombocytopenia, recurrent pregnancy loss, postnatal maternal complications, migraine headaches, cerebrovascular accident, transientischemic attack, or stroke.

Notes:

See APA and LAC tests descriptions for more information.

Reference(s)

• Hughes GRV: The antiphospholipid syndrome: 10 years on. Lancet 1993, 342:341.