Anti-Thyroglobulin Antibodies (ATGA)

Rheumatic Disease Laboratory

Indirect immunofluorescence (monkey thyroid substrate)

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Specimen Required:

Serum: Adult 2 mL,   Child 0.2 mL

Room temperature or 4°C

Days Test Set Up:

Twice per week

Analytic Time:

48 hours

Reference Values:

Normal: < 1:10 titer

CPT Code(s):

86800

Relevance:

Thyroglobulin antibodies are seen in patients with Hashimoto's thyroiditis and Graves' disease. They may also be seen at lower levels in other thyroid and non-thyroid autoimmune diseases.

Notes:

ATGA is also included as part of the Block II.

Reference(s)

• Larsen PR: The thyroid. In: Cecil Textbook of Medicine, Wyngaarden JB, Smith LH, Bennett JC (eds). Vol. 2, 19th Edition., W.B. Saunders Company: Philadelphia, PA, p. 1253, 1992.
• Bulow Pedersen I, Laurberg P, Knudsen N, Jorgensen T, Perrild H, Ovesen L, Rasmussen LB. A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure. Clin Endocrinol (Oxf), 62;6:713-20, 2005.