Cryoglobulin and Euglobulin (CRYO)

Rheumatic Disease Laboratory

Cold precipitation under controlled conditions: serum and plasma must be drawn and separated at 37°C.

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Specimen Required:

Serum/Plasma: Adult 4 mL,   Child 2 mL

Draw and centrifuge at 37°C; Refer to Special Handling Requirements

Days Test Set Up:

Monday - Friday

Analytic Time:

7 days

Reference Values:

0 to trace = Normal

CPT Code(s):

82585, 82595
Reflexive: 86334

Relevance:

Cryoprotein testing should be ordered when cutaneous vasculitis is present, when cold sensitivity with cyanosis of digits, ears, and nose is seen, and also when cryoproteinemia is suspected.

Notes:

Immunofixation will be performed on any observed cryoprecipitate.

Reference(s)

• Kyle RA: Plasma cell disorders. In: Cecil Textbook of Medicine, Wyngaarden JB, Smith LH, Bennett JC (eds). Vol. 1, 19th Edition. W.B. Saunders Company, Philadelphia, PA, pp. 967-978, 1992.
• Craig WY, Ledue TB, Ritchie RF: Plasma Proteins Clinical Utility and Interpretation, published by Dade Behring, 2001.