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Anti-Glomerular Basement Membrane Antibodies (GBM)
Indirect immunofluorescence; monkey kidney substrate
Rheumatic Disease Laboratory
Specimen Required:
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Serum: Adult 2 mL
Child 0.2 mL
Room temperature or 4°C
| Days Test Set Up:
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Monday - Friday
| Analytic Time:
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48 hours
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Reference Values:
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Normal: < 1:10 titer
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|
IgG |
IgA |
Seronegative |
<20 |
<20 |
Weak positive |
20-30 |
20-30 |
Moderate/strong positive |
>30 |
>30 |
| CPT Code(s):
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86255
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Relevance
Anti-GBM testing is useful in diagnosing Goodpasture’s Syndrome and other immune-mediated causes of rapidly progressive glomerulonephritis (RPGN). In some patients with RPGN, antibodies to GBM and anti-neutrophil cytoplasmic antibodies (ANCA) may coexist.
Notes
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Reference(s)
- Wilson CB: The renal response to immunological injury: In: Brenner BM, Rector FC Jr. The Kidney, ed.4. WB Saunders Company: Philadelphia, PA, 1991.
- Sinico RA, Radice A, Corace C, Sabadini E, Bollini B. Anti-glomerular basement membrane antibodies in the diagnosis of Goodpasture syndrome: a comparison of different assays. Nephrol Dial Transplant, 21;2:397-401, 2006.
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